If you are getting errors along the line of “406 Not acceptable. Can’t find appropriate resource” with your Wordpress installations, it is most likely a case of too strict security.
This could easily be solved by editing .htaccess files and adding appropriate code that turns off Mod Security for specific files and directories.
If you have a new server (with Apache 2.x and up and Mod Security 2.x and up) this can no longer be done. You can no longer edit Mod Security through .htaccess files.
It can only be done with the config files. You can’t change it, so you must contact your host and ask to disable mod security for certain files and directories.